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Article

Mechanisms of Suppression of α-Synuclein Neurotoxicity by Geldanamycin in Drosophila

20 Nov 2004

Abstract excerpt

Parkinson's disease is a common neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta and the accumulation of the protein alpha-synuclein into aggregates called Lewy bodies and Lewy neurites. Parkinson's disease can be modeled in Drosophila where directed expression of alpha-synuclein induces compromise of dopaminergic neurons and the formation of Lewy...

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PMID: 15556931
DOI: 10.1074/jbc.m412106200

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