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Article

Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 21 Mar 2007

Periquet Magali, Fulga Tudor, Myllykangas Liisa, Schlossmacher Michael G, Feany Mel B

Abstract excerpt

Mutations in the synaptic protein alpha-synuclein cause rare genetic forms of Parkinson's disease. Alpha-synuclein is thought to play a critical role in more common sporadic cases of Parkinson's disease as well because the protein aggregates in the hallmark intraneuronal inclusions of the disorder, Lewy bodies. To test the role of protein aggregation in the pathogenesis of Parkinson's disease, we expressed a form...

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Identifiers

PMID: 17376994
DOI: 10.1523/JNEUROSCI.0285-07.2007
PMCID: PMC6672466

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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