Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GON-1 and fibulin have antagonistic roles in control of organ shape.

Current biology : CB - 23 Nov 2004

Hesselson Daniel, Newman Craig, Kim Kyung Won, Kimble Judith

Abstract excerpt

Most developing organs are surrounded by an extracellular matrix (ECM), which must be remodeled to accommodate growth and morphogenesis. In C. elegans, the GON-1 ADAMTS metalloprotease regulates both elongation and shape of the developing gonad . Here, we report that either human ADAMTS-4 or ADAMTS-9 can substitute for GON-1 in transgenic worms, suggesting functional conservation between human and nematode...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADAM Proteins
Share to Animals, Genetically Modified
Share to Caenorhabditis elegans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caenorhabditis elegans Proteins

Share to Calcium-Binding Proteins

Share to Gonads

Share to Metalloendopeptidases

Share to Morphogenesis

Source

Identifiers

PMID: 15556862
DOI: 10.1016/j.cub.2004.11.006

Genes

FBL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GON-1 and fibulin have antagonistic roles in control of organ shape.PMID 15556862Read ↗

Tissue architecture in the Caenorhabditis elegans gonad depends on interactions among fibulin-1, type IV collagen and the ADAMTS extracellular protease.Semantic proximity Read ↗

The gon-1 gene is required for gonadal morphogenesis in Caenorhabditis elegans.Semantic proximity Read ↗

A fibulin-1 homolog interacts with an ADAM protease that controls cell migration in C. elegans.Semantic proximity Read ↗

Organ Length Control by an ADAMTS Extracellular Protease in Caenorhabditis elegans.Semantic proximity Read ↗

Genetic interactions among ADAMTS metalloproteases and basement membrane molecules in cell migration in Caenorhabditis elegans.Semantic proximity Read ↗

Development. A degrading way to make an organ.Semantic proximity Read ↗

Genetics of extracellular matrix remodeling during organ growth using the Caenorhabditis elegans pharynx model.Semantic proximity Read ↗

Regulation of synaptic extracellular matrix composition is critical for proper synapse morphology.Semantic proximity Read ↗

Fibulin-1C and Fibulin-1D splice variants have distinct functions and assemble in a hemicentin-dependent manner.Semantic proximity Read ↗

Epithelial Shaping by Diverse Apical Extracellular Matrices Requires the Nidogen Domain Protein DEX-1 in Caenorhabditis elegansSemantic proximity Read ↗

bHLH transcription factors regulate organ morphogenesis via activation of an ADAMTS protease in C. elegans.Semantic proximity Read ↗

An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.