Article
bHLH transcription factors regulate organ morphogenesis via activation of an ADAMTS protease in C. elegans.
Developmental biology - 15 Aug 2007
Tamai Katsuyuki K, Nishiwaki Kiyoji
Abstract excerpt
The ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) family of secreted metalloproteases plays important roles in animal development and pathogenesis. However, transcriptional regulation of ADAMTS proteins during development remains largely unexplored. Here we show that basic helix-loop-helix (bHLH) transcription factors regulate the expression of an ADAMTS protease that is required for gonad...
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