Article
Development. A degrading way to make an organ.
Science (New York, N.Y.) - 23 Jun 2000
Hardin J
Abstract excerpt
Working out how organs form during embryonic development is a fascinating area of research. In a witty Perspective, Jeff Hardin describes new findings (Nishiwaki et al.) that reveal the many intricate steps needed for gonads to form in the worm C. elegans. Two key players, GON-1 and MIG-17, are metalloproteases that may help migration of distal tip cells by degrading extracellular matrix components.
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