Article
A novel nucleolar protein, PAPA-1, induces growth arrest as a result of cell cycle arrest at the G1 phase.
Gene - 29 Sept 2004
Kuroda Taruho S, Maita Hiroshi, Tabata Takanori, Taira Takahiro, Kitaura Hirotake, Ariga Hiroyoshi, Iguchi-Ariga Sanae M M
Abstract excerpt
We have identified a novel nucleolar protein, PAP-1-associated protein-1 (PAPA-1), after screening the interacting proteins with Pim-1-associated protein-1 (PAP-1), a protein that is a phosphorylation target of Pim-1 kinase. PAPA-1 comprises 345 amino acids with a basic amino-acid cluster. PAPA-1 was found to be localized in the nucleolus in transfected HeLa cells, and the lysine/histidine cluster was essential...
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