Article
Antimitochondrial antibodies and reactivity to N. aromaticivorans proteins in Icelandic patients with primary biliary cirrhosis and their relatives.
The American journal of gastroenterology - 1 Nov 2004
Olafsson Sigurdur, Gudjonsson Hallgrimur, Selmi Carlo, Amano Katsushi, Invernizzi Pietro, Podda Mauro, Gershwin M Eric
Abstract excerpt
OBJECTIVES: Primary biliary cirrhosis (PBC) is a chronic, progressive cholestatic disease of unknown etiology characterized by serum antimitochondrial antibodies (AMA) directed against a functionally related family of mitochondrial enzymes. We recently suggested that N. aromaticivorans might be the trigger of autoimmunity in PBC. No data are available on the specificity and crossreactivity of AMA in a genetically...
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