Article
Low incidence of primary biliary cirrhosis (PBC) in the first-degree relatives of PBC probands after 8 years of follow-up.
Liver international : official journal of the International Association for the Study of the Liver - 1 Sept 2016
Gulamhusein Aliya F, Juran Brian D, Atkinson Elizabeth J, McCauley Bryan, Schlicht Erik, Lazaridis Konstantinos N
Abstract excerpt
BACKGROUND & AIMS: Primary biliary cirrhosis (PBC) is characterized by chronic cholestasis and disease-specific antimitochondrial antibodies (AMA). A high prevalence of AMAs in first-degree relatives (FDRs) of PBC probands has been reported, although the natural history of such patients has not been described. We aimed to assess the risk of developing PBC in AMA+ FDRs of patients with PBC. METHODS: First-degree...
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