<i>Drosophila melanogaster</i> NEP2 is a new soluble member of the neprilysin family of endopeptidases with implications for reproduction and renal function

Abstract excerpt

The mammalian neprilysin (NEP) family members are typically type II membrane endopeptidases responsible for the activation/inactivation of neuropeptides and peptide hormones. Differences in substrate specificity and subcellular localization of the seven mammalian NEPs contribute to their functional diversity. The sequencing of the Drosophila melanogaster genome has revealed a large expansion of this gene family,...

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