Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila.

Genetics - 1 Mar 2014

Sitnik Jessica L, Francis Carmen, Hens Korneel, Huybrechts Roger, Wolfner Mariana F, Callaerts Patrick

Abstract excerpt

Members of the M13 class of metalloproteases have been implicated in diseases and in reproductive fitness. Nevertheless, their physiological role remains poorly understood. To obtain a tractable model with which to analyze this protein family's function, we characterized the gene family in Drosophila melanogaster and focused on reproductive phenotypes. The D. melanogaster genome contains 24 M13 class protease...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila melanogaster
Share to Drosophila Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fertility

Share to Genetic Fitness

Share to Models, Animal

Share to Neprilysin

Share to Organ Specificity

Share to Reproduction

Source

Open in PubMed Open full text

Identifiers

PMID: 24395329
DOI: 10.1534/genetics.113.160945
PMCID: PMC3948806

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila.PMID 24395329Read ↗

<i>Drosophila melanogaster</i> NEP2 is a new soluble member of the neprilysin family of endopeptidases with implications for reproduction and renal functionSemantic proximity Read ↗

Drosophila melanogaster p24 trafficking proteins have vital roles in development and reproduction.Semantic proximity Read ↗

Bioinformatic analysis of the neprilysin (M13) family of peptidases reveals complex evolutionary and functional relationshipsSemantic proximity Read ↗

A Drosophila protease cascade member, seminal metalloprotease-1, is activated stepwise by male factors and requires female factors for full activity.Semantic proximity Read ↗

The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in miceSemantic proximity Read ↗

The Drosophila melanogaster seminal fluid protease "seminase" regulates proteolytic and post-mating reproductive processes.Semantic proximity Read ↗

Proteolysis in Reproduction: Lessons From Gene-Modified Organism StudiesSemantic proximity Read ↗

Targeted gene deletion and phenotypic analysis of the Drosophila melanogaster seminal fluid protease inhibitor Acp62F.Semantic proximity Read ↗

Reduced fertility in male mice deficient in the zinc metallopeptidase NL1.Semantic proximity Read ↗

Optimal male fertility and fecundity in Caenorhabditis elegans require Microprocessor and Argonaute gene function.Semantic proximity Read ↗

Identification and function of proteolysis regulators in seminal fluidSemantic proximity Read ↗

The role of multifunctional M1 metallopeptidases in cell cycle progressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.