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Bioinformatic analysis of the neprilysin (M13) family of peptidases reveals complex evolutionary and functional relationships

1 Jan 2008

Abstract excerpt

BACKGROUND: The neprilysin (M13) family of endopeptidases are zinc-metalloenzymes, the majority of which are type II integral membrane proteins. The best characterised of this family is neprilysin, which has important roles in inactivating signalling peptides involved in modulating neuronal activity, blood pressure and the immune system. Other family members include the endothelin converting enzymes (ECE-1 and...

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PMID: 18215274
DOI: 10.1186/1471-2148-8-16

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