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A small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertility

24 Apr 2023

Abstract excerpt

The mammalian spermatozoa produced in the testis require functional maturation in the epididymis for their full competence. Epididymal sperm maturation is regulated by lumicrine signalling pathways in which testis-derived secreted signals relocate to the epididymis lumen and promote functional differentiation. However, the detailed mechanisms of lumicrine regulation are unclear. Herein, we demonstrate that a...

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PMID: 37095084
DOI: 10.1038/s41467-023-37984-x

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