Article
Screening of the interaction between xenobiotic transporters and PDZ proteins.
Pharmaceutical research - 1 Oct 2004
Kato Yukio, Yoshida Kazuhiro, Watanabe Chizuru, Sai Yoshimichi, Tsuji Akira
Abstract excerpt
PURPOSE: Xenobiotic transporters have been proposed to be involved in membrane penetration of various therapeutic agents. As little information is available on molecular mechanism of their functional regulation, we have attempted to clarify the protein-protein interactions of such transporters as a first step to identify their regulators. METHODS: Yeast two-hybrid screening was performed to examine the...
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