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Article

PDZK1 binding and serine phosphorylation regulate subcellular trafficking of organic anion transport protein 1a1.

American journal of physiology. Gastrointestinal and liver physiology - 1 Mar 2011

Choi Jo H, Murray John W, Wolkoff Allan W

Abstract excerpt

Although perturbation of organic anion transport protein (oatp) cell surface expression can result in drug toxicity, little is known regarding mechanisms regulating its subcellular distribution. Many members of the oatp family, including oatp1a1, have a COOH-terminal PDZ consensus binding motif that interacts with PDZK1, while serines upstream of this site (S634 and S635) can be phosphorylated. Using oatp1a1 as a...

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Source

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Identifiers

PMID: 21183661
DOI: 10.1152/ajpgi.00500.2010
PMCID: PMC3064118

Genes

PDZK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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