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Article

Mutation in an adaptor protein PDZK1 affects transport activity of organic cation transporter OCTNs and oligopeptide transporter PEPT2.

Drug metabolism and pharmacokinetics - 1 Oct 2006

Sugiura Tomoko, Kato Yukio, Kubo Yoshiyuki, Tsuji Akira

Abstract excerpt

Genetic polymorphisms in xenobiotic transporters have recently been clarified to be associated with change in drug distribution and disposition. To expand on recent identification of direct interaction and functional regulation of several transporters by a PDZ (PSD95, Dlg and ZO1) domain containing protein PDZK1, the effect of mutation in PDZK1 on transport activity and subcellular localization of organic...

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Source

Identifiers

PMID: 17072090
DOI: 10.2133/dmpk.21.375

Genes

PDZK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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