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Article

Species comparison of in vivo P-glycoprotein-mediated brain efflux using mdr1a-deficient rats and mice.

Drug metabolism and disposition: the biological fate of chemicals - 1 Mar 2012

Bundgaard Christoffer, Jensen Christian Jes Nyberg, Garmer Mats

Abstract excerpt

The experiments described herein compared the extent of in vivo P-glycoprotein (P-gp)-mediated brain efflux between rats and mice for a set of known central nervous system compounds. With use of newly introduced genetically modified mdr1a-deficient rats and their gene-competent counterparts, the brain to plasma distribution was assessed and compared with the distribution pattern in mdr1a-deficient and wild-type...

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PMID: 22112383
DOI: 10.1124/dmd.111.043083

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