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Article

Regional expression of multidrug resistance genes in genetically epilepsy-prone rat brain after a single audiogenic seizure.

Epilepsia - 1 Nov 2002

Kwan Patrick, Sills Graeme J, Butler Elaine, Gant Timothy W, Meldrum Brian S, Brodie Martin J

Abstract excerpt

PURPOSE: The multidrug resistance (mdr) gene family encodes the drug transport macromolecule P-glycoprotein (P-gp), which contributes to the functionality of the blood-brain barrier. Recent evidence suggests that P-gp-mediated drug extrusion may play a facilitatory role in refractory epilepsy. We investigated the regional expression of mdr genes in genetically epilepsy-prone rat (GEPR) brain after a single...

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Source

Identifiers

PMID: 12423380
DOI: 10.1046/j.1528-1157.2002.156702.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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