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Article

The optimal measure of linkage disequilibrium reduces error in association mapping of affection status.

Human molecular genetics - 1 Jan 2005

Maniatis N, Morton N E, Gibson J, Xu C-F, Hosking L K, Collins A

Abstract excerpt

We have developed a simple yet powerful approach for disease gene association mapping by linkage disequilibrium (LD). This method is unique because it applies a model with evolutionary theory that incorporates a parameter for the location of the causal polymorphism. The method exploits LD maps, w...

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Share to Chromosomes, Human, Pair 22
Share to Cytochrome P-450 CYP2D6
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inactivation, Metabolic

Share to Linkage Disequilibrium

Share to Models, Genetic

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 15548543
DOI: 10.1093/hmg/ddi019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15548543-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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