Article
Analysis of the Escherichia coli Alp phenotype: heat shock induction in ssrA mutants.
Journal of bacteriology - 1 Jul 2005
Munavar Hussain, Zhou Yanning, Gottesman Susan
Abstract excerpt
The major phenotypes of lon mutations, UV sensitivity and overproduction of capsule, are due to the stabilization of two substrates, SulA and RcsA. Inactivation of transfer mRNA (tmRNA) (encoded by ssrA), coupled with a multicopy kanamycin resistance determinant, suppressed both lon phenotypes and restored the rapid degradation of SulA. This novel protease activity was named Alp but was never identified further....
Topics
- Chromosomes, Bacterial
- Escherichia coli
- Heat-Shock Proteins
- Hot Temperature
- Methyl Methanesulfonate
- Mutagenesis
- Mutagens
- Mutation
- Nitrosoguanidines
- Phenotype
- RNA, Bacterial
- Ultraviolet Rays