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Article

Ribosome release factor RF4 and termination factor RF3 are involved in dissociation of peptidyl-tRNA from the ribosome.

The EMBO journal - 2 Feb 1998

Heurgué-Hamard V, Karimi R, Mora L, MacDougall J, Leboeuf C, Grentzmann G, Ehrenberg M, Buckingham R H

Abstract excerpt

Peptidyl-tRNA dissociation from ribosomes is an energetically costly but apparently inevitable process that accompanies normal protein synthesis. The drop-off products of these events are hydrolysed by peptidyl-tRNA hydrolase. Mutant selections have been made to identify genes involved in the dro...

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Identifiers

PMID: 9451005
DOI: 10.1093/emboj/17.3.808
PMCID: PMC1170429

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9451005-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ribosome release factor RF4 and termination factor RF3 are involved in dissociation of peptidyl-tRNA from the ribosome.PMID 9451005Read ↗

A novel class of bacterial translation factor RF3 mutations suggests specific structural domains for premature peptidyl-tRNA drop-off.Semantic proximity Read ↗

Evidence for a role of initiation factor 3 in recycling of ribosomal complexes stalled on mRNAs in Escherichia coli.Semantic proximity Read ↗

Stop codon recognition and interactions with peptide release factor RF3 of truncated and chimeric RF1 and RF2 from Escherichia coli.Semantic proximity Read ↗

Release of peptide promoted by the GGQ motif of class 1 release factors regulates the GTPase activity of RF3.Semantic proximity Read ↗

Release factor RF3 abolishes competition between release factor RF1 and ribosome recycling factor (RRF) for a ribosome binding site.Semantic proximity Read ↗

Interactions of release factor RF3 with the translation machinery.Semantic proximity Read ↗

Mechanism of Translation Termination: RF1 Dissociation Follows Dissociation of RF3 from the Ribosome.Semantic proximity Read ↗

A physiological connection between tmRNA and peptidyl-tRNA hydrolase functions in Escherichia coli.Semantic proximity Read ↗

The essential role of the invariant GGQ motif in the function and stability <i>in vivo</i> of bacterial release factors RF1 and RF2Semantic proximity Read ↗

Suppression of temperature-sensitive defects of polypeptide release factors RF-1 and RF-2 by mutations or by an excess of RF-3 in Escherichia coli.Semantic proximity Read ↗

Mutations in conserved regions of ribosomal RNAs decrease the productive association of peptide-chain release factors with the ribosome during translation termination.Semantic proximity Read ↗

Recycling of ribosomal complexes stalled at the step of elongation in Escherichia coli.Semantic proximity Read ↗

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