Article
Association of HLA-DM polymorphism with the production of antiphospholipid antibodies.
Annals of the rheumatic diseases - 1 Dec 2004
Sanchez M L, Katsumata K, Atsumi T, Romero F I, Bertolaccini M L, Funke A, Amengual O, Kondeatis E, Vaughan R W, Cox A, Hughes G R V, Khamashta M A
Abstract excerpt
OBJECTIVE: To investigate whether variation in the HLA-DM gene is important in producing a group of pathogenic autoantibodies-antiphospholipid antibodies (aPL)-on the basis that HLA class II restricted antigen presentation is involved in the production of aPL. METHODS: HLA-DMA and DMB polymorphisms were genotyped by polymerase chain reaction combined with restriction enzyme digestion in 51 white patients with...
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