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Article

Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography.

The Journal of clinical investigation - 1 Nov 2004

Wartiovaara Jorma, Ofverstedt Lars-Göran, Khoshnoodi Jamshid, Zhang Jingjing, Mäkelä Eetu, Sandin Sara, Ruotsalainen Vesa, Cheng R Holland, Jalanko Hannu, Skoglund Ulf, Tryggvason Karl

Abstract excerpt

Nephrin is a key functional component of the slit diaphragm, the structurally unresolved molecular filter in renal glomerular capillaries. Abnormal nephrin or its absence results in severe proteinuria and loss of the slit diaphragm. The diaphragm is a thin extracellular membrane spanning the appr...

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Identifiers

PMID: 15545998
DOI: 10.1172/JCI22562
PMCID: PMC525744

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15545998-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography.PMID 15545998Read ↗

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Revisiting nephrin signaling and its specialized effects on the uniquely adaptable podocyteSemantic proximity Read ↗

Nephrin Signaling in the Podocyte: An Updated View of Signal Regulation at the Slit Diaphragm and BeyondSemantic proximity Read ↗

Three-dimensional electron microscopy reveals the evolution of glomerular barrier injurySemantic proximity Read ↗

Selective endocytosis controls slit diaphragm maintenance and dynamicsSemantic proximity Read ↗

Collagen IV of basement membranes: II. Emergence of collagen IVα345 enabled the assembly of a compact GBM as an ultrafilter in mammalian kidneysSemantic proximity Read ↗

An update: the role of Nephrin inside and outside the kidneySemantic proximity Read ↗

Structural conformations of intrinsically disordered proteins of podocyte slit-diaphragmSemantic proximity Read ↗

Super‐resolved local recruitment of CLDN5 to filtration slits implicates a direct relationship with podocyte foot process effacementSemantic proximity Read ↗

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