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Collagen IV of basement membranes: II. Emergence of collagen IVα345 enabled the assembly of a compact GBM as an ultrafilter in mammalian kidneys

15 Nov 2023

Abstract excerpt

The collagen IV α345 (Col-IV α345 ) scaffold, the major constituent of the glomerular basement membrane (GBM), is a critical component of the kidney glomerular filtration barrier. In chronic kidney disease, affecting hundreds of millions of people worldwide, over two thousand genetic variants occur in the COL4A3 , COL4A4 , and COL4A5 genes that encode the Col-IV α345 scaffold. Variants cause loss of scaffold, a...

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PMID: 37977222
DOI: 10.1016/j.jbc.2023.105459

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