Article
Dll3 pudgy mutation differentially disrupts dynamic expression of somite genes.
Genesis (New York, N.Y. : 2000) - 1 Jun 2004
Kusumi Kenro, Mimoto Mizuho S, Covello Kelly L, Beddington Rosa S P, Krumlauf Robb, Dunwoodie Sally L
Abstract excerpt
Mutations in the notch ligand delta-like 3 have been identified in both the pudgy mouse (Dll3(pu); Kusumi et al.: Nat Genet 19:274-278, 1998) and the human disorder spondylocostal dysostosis (SCD; Bulman et al.: Nat Genet 24:438-441, 2000), and a targeted mutation has been generated (Dll3(neo); Dunwoodie et al.: Development 129:1795-1806, 2002). Vertebral and rib malformations deriving from defects in somitic...
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