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Article

APOE-dependent PET patterns of brain activation in Alzheimer disease.

Neurology - 14 Sept 2004

Scarmeas N, Anderson K E, Hilton J, Park A, Habeck C, Flynn J, Tycko B, Stern Y

Abstract excerpt

Using H2(15)O PET, the authors imaged 13 patients with Alzheimer disease (AD) while performing a serial nonverbal recognition memory task. Patterns of brain activation differed as a function of APOE genotype: epsilon4 carriers exhibited lower activation in the left lingual gyrus and higher activation in left cuneus, precuneus, parahippocampal, and right precentral gyrus. The APOE genotype seems to play a role in...

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Identifiers

PMID: 15365149
DOI: 10.1212/01.wnl.0000137274.93125.46
PMCID: PMC3026570

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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