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Article

Crystal structures of the FXIa catalytic domain in complex with ecotin mutants reveal substrate-like interactions.

The Journal of biological chemistry - 11 Feb 2005

Jin Lei, Pandey Pramod, Babine Robert E, Gorga Joan C, Seidl Katherine J, Gelfand Ellen, Weaver David T, Abdel-Meguid Sherin S, Strickler James E

Abstract excerpt

Thrombosis can lead to life-threatening conditions such as acute myocardial infarction, pulmonary embolism, and stroke. Although commonly used anti-coagulant drugs, such as low molecular weight heparin and warfarin, are effective, they carry a significant risk of inducing severe bleeding complications, and there is a need for safer drugs. Activated Factor XI (FXIa) is a key enzyme in the amplification phase of...

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PMID: 15545266
DOI: 10.1074/jbc.M411309200

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