Article
Audiogenic seizure susceptibility is reduced in fragile X knockout mice after introduction of FMR1 transgenes.
Experimental neurology - 1 Jan 2007
Musumeci Sebastiano A, Calabrese Giuseppe, Bonaccorso Carmela M, D'Antoni Simona, Brouwer Judith R, Bakker Cathy E, Elia Maurizio, Ferri Raffaele, Nelson David L, Oostra Ben A, Catania Maria Vincenza
Abstract excerpt
The Fmr1 knockout (KO) mouse is characterized by an increased audiogenic seizure (AGS) susceptibility and is considered a good animal model for epilepsy and seizures in the human fragile-X (FRAX) syndrome. Here, we tested the hypothesis that the reintroduction of the FMR1 gene is able to revert the AGS susceptibility characterizing Fmr1 KO mice. To this aim, two groups of Fmr1 KO transgenic mice, which have...
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