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Article

Hsp70 mutant proteins modulate additional apoptotic pathways and improve cell survival.

Cell stress & chaperones - 1 Jan 2004

Ran Ruiqiong, Zhou Guoping, Lu Aigang, Zhang Lu, Tang Yang, Rigby Alan C, Sharp Frank R

Abstract excerpt

Although wild-type Hsp70 (Hsp70WT) inhibits procaspase-3 processing by preventing apoptosome formation, Hsp70WT does not block active caspase-3. Because all caspase-3 inhibitors bear canonical DXXD caspase-3 recognition motifs, we determined whether mutated Hsp70s with caspase-binding motifs act...

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Identifiers

PMID: 15544161
DOI: 10.1379/csc-19r.1
PMCID: PMC1065282

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15544161-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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