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Article

N-terminal and C-terminal modulation of Hsp90 produce dissimilar phenotypes.

Chemical communications (Cambridge, England) - 28 Jan 2015

Wang Y, McAlpine S R

Abstract excerpt

Classic oncogenic heat shock protein 90 (Hsp90) inhibitors target the N-terminus of the protein, triggering a survival mechanism in cancer cells referred to as the heat shock response (HSR). Inhibiting Hsp90 by modulating the C-terminus does not trigger a HSR, making it a highly attractive chemotherapeutic approach.

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Identifiers

PMID: 25333923
DOI: 10.1039/c4cc07284g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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