Article
Unraveling the genetics of cancer: genome sequencing and beyond.
Annual review of genomics and human genetics - 1 Jan 2011
Wong Kit Man, Hudson Thomas J, McPherson John D
Abstract excerpt
Advances in next-generation sequencing technology are enabling the systematic analyses of whole cancer genomes, providing insights into the landscape of somatic mutations and the great genetic heterogeneity that defines the unique signature of an individual tumor. Moreover, integrated studies of the genome, epigenome, and transcriptome reveal mechanisms of tumorigenesis at multiple levels. Progress in sequencing...
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