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Article

CYP2D6 genotype and its relationship with metoprolol dose, concentrations and effect in patients with systolic heart failure.

The pharmacogenomics journal - 1 Jun 2009

Sharp C F, Gardiner S J, Jensen B P, Roberts R L, Troughton R W, Lainchbury J G, Begg E J

Abstract excerpt

The aims of this study were to examine the relationships between CYP2D6 genotype and metoprolol dose, S- and R-metoprolol concentrations and clinical effects in patients with systolic heart failure. Data were obtained for 52 subjects, of which 27 had 2 functional alleles (24/27, CYP2D6*1/*1), 22 had 1 functional allele (18/22, CYP2D6*1/*4) and 3 had no functional alleles (CYP2D6*4/*4). Median dose-adjusted...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19365402
DOI: 10.1038/tpj.2009.9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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