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Article

Influence of CYP2D6 genotype on metoprolol plasma concentration and beta-adrenergic inhibition during long-term treatment: a comparison with bisoprolol.

Journal of cardiovascular pharmacology - 1 Nov 2005

Nozawa Takashi, Taguchi Masato, Tahara Katsutoshi, Hashimoto Yukiya, Igarashi Norio, Nonomura Makoto, Kato Bun-ichi, Igawa Akihiko, Inoue Hiroshi

Abstract excerpt

In patients routinely treated with metoprolol, influences of CYP2D6 genotype on the response of heart rate to isoproterenol (IP) were studied at its peak and trough concentrations and were compared with those of bisoprolol. In 72 patients treated with metoprolol or bisoprolol, CYP2D6 genotype (ie, CYP2D6*1, *2, *4, *5, *10, and *14) was determined. No patients except one who was heterozygous for CYP2D6*5 carried...

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Share to Adrenergic beta-Antagonists
Share to Circadian Rhythm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2D6

Share to Drug Administration Schedule

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Share to Metabolic Clearance Rate

Share to Metoprolol

Share to Receptors, Adrenergic, beta

Source

Identifiers

PMID: 16220080
DOI: 10.1097/01.fjc.0000184117.76188.68

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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