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Article

DNA topoisomerase I is essential in Drosophila melanogaster.

Proceedings of the National Academy of Sciences of the United States of America - 15 Jul 1993

Lee M P, Brown S D, Chen A, Hsieh T S

Abstract excerpt

Both biochemical and genetic experiments suggest that the type I DNA topoisomerase may participate in DNA replication, recombination, transcription, and other aspects of DNA metabolism. Despite its apparent importance, genetic studies in unicellular organisms including eubacteria and yeasts indicate that topoisomerase I is not essential for viability. We have previously isolated the cDNA clone encoding DNA...

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Identifiers

PMID: 8393572
DOI: 10.1073/pnas.90.14.6656
PMCID: PMC46991

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Source receipt: pubmed, retrieved 7 Sept 2026.

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