Article
DNA topoisomerase I is essential in Drosophila melanogaster.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jul 1993
Lee M P, Brown S D, Chen A, Hsieh T S
Abstract excerpt
Both biochemical and genetic experiments suggest that the type I DNA topoisomerase may participate in DNA replication, recombination, transcription, and other aspects of DNA metabolism. Despite its apparent importance, genetic studies in unicellular organisms including eubacteria and yeasts indic...
Topics
- Animals
- Chromosome Mapping
- Cloning, Molecular
- Crosses, Genetic
- DNA Topoisomerases, Type I
- Drosophila melanogaster
- Genes, Insect
- Genes, Lethal
- In Situ Hybridization
- Mutagenesis, Insertional
- Mutation
- Sequence Analysis, DNA
- Sex Characteristics
- Transcription, Genetic
- X Chromosome