Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumor necrosis factor promotes human T-cell development in nonobese diabetic/severe combined immunodeficient mice.

Stem cells (Dayton, Ohio) - 1 Jan 2004

Samira Sarit, Ferrand Christophe, Peled Amnon, Nagler Arnon, Tovbin Yosef, Ben-Hur Herzl, Taylor Naomi, Globerson Amiela, Lapidot Tsvee

Abstract excerpt

A major problem after clinical hematopoietic stem cell transplantations is poor T-cell reconstitution. Studying the mechanisms underlying this concern is hampered, because experimental transplantation of human stem and progenitor cells into nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice usually results in low T-lymphocyte reconstitution. Because tumor necrosis factor alpha (TNFalpha) has been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Transplantation
Share to CD4 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD8 Antigens

Share to Cell Transplantation

Share to Granulocyte Colony-Stimulating Factor

Share to Mice, Inbred NOD

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to Stem Cell Transplantation

Source

Identifiers

PMID: 15536198
DOI: 10.1634/stemcells.22-6-1085

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumor necrosis factor promotes human T-cell development in nonobese diabetic/severe combined immunodeficient mice.PMID 15536198Read ↗

Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor-, granulocyte-macrophage colony-stimulating factor-, and interleukin-3-expressing NOD-SCID IL2Rγ(null) humanized mice.Semantic proximity Read ↗

A new xenograft model for graft-versus-host disease by intravenous transfer of human peripheral blood mononuclear cells in RAG2-/- gammac-/- double-mutant mice.Semantic proximity Read ↗

Transgenic expression of human signal regulatory protein alpha in Rag2 <sup>−/−</sup> γ <sub>c</sub> <sup>−/−</sup> mice improves engraftment of human hematopoietic cells in humanized miceSemantic proximity Read ↗

Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors.Semantic proximity Read ↗

CD8 <sup>+</sup> minor histocompatibility antigen-specific cytotoxic T lymphocyte clones eliminate human acute myeloid leukemia stem cellsSemantic proximity Read ↗

TNF-alpha, the great imitator: role of p55 and p75 TNF receptors in hematopoiesis.Semantic proximity Read ↗

Human T cells in the SCID-hu mouse are phenotypically normal and functionally competent.Semantic proximity Read ↗

Restoration of Human B-cell Differentiation Into NOD-SCID Mice Engrafted With Gene-corrected CD34+ Cells Isolated From Artemis or RAG1-deficient PatientsSemantic proximity Read ↗

A novel immunodeficient mouse model--RAG2 x common cytokine receptor gamma chain double mutants--requiring exogenous cytokine administration for human hematopoietic stem cell engraftment.Semantic proximity Read ↗

Inhibition of CD26 in human cord blood CD34+ cells enhances their engraftment of nonobese diabetic/severe combined immunodeficiency mice.Semantic proximity Read ↗

Patterns of engraftment in different strains of immunodeficient mice reconstituted with human peripheral blood lymphocytes.Semantic proximity Read ↗

Conserved and divergent aspects of human T-cell development and migration in humanized mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.