Article
The leucine-rich repeat-containing G protein-coupled receptor 8 gene T222P mutation does not cause cryptorchidism.
The Journal of clinical endocrinology and metabolism - 1 Mar 2008
Nuti Francesca, Marinari Eliana, Erdei Edit, El-Hamshari Manal, Echavarria Mirna Guadalupe, Ars Elisabet, Balercia Giancarlo, Merksz Miklos, Giachini Claudia, Shaeer Kamal Zaki Mahmoud, Forti Gianni, Ruiz-Castané Eduard, Krausz Csilla
Abstract excerpt
CONTEXT: Insulin-like 3 and its receptor, leucine-rich repeat-containing G protein-coupled receptor 8 (LGR8), are essential for the first phase of testicular descent. Homozygous loss of either of the two genes in mice leads to cryptorchidism. Although mutations in both homologous human genes are...
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