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Article

Hydrophobic helical hairpins: design and packing interactions in membrane environments.

Biochemistry - 16 Nov 2004

Johnson Rachel M, Heslop Claire L, Deber Charles M

Abstract excerpt

Helix-helix interactions within membranes are dominated by van der Waals packing motifs and side chain-side chain hydrogen bond formation, which act in tandem to determine the residues that comprise the interface between two given helices. To explore in a systematic manner the tertiary contacts between transmembrane helices, we have designed and expressed in Escherichia coli highly hydrophobic helix-loop-helix...

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PMID: 15533040
DOI: 10.1021/bi0492760

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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