Article
Lipid solvation effects contribute to the affinity of Gly-xxx-Gly motif-mediated helix-helix interactions.
Biochemistry - 18 Jul 2006
Johnson Rachel M, Rath Arianna, Melnyk Roman A, Deber Charles M
Abstract excerpt
Interactions between transmembrane helices are mediated by the concave Gly-xxx-Gly motif surface. Whether Gly residues per se are sufficient for selection of this motif has not been established. Here, we used the in vivo TOXCAT assay to measure the relative affinities of all 18 combinations of Gly, Ala, and Ser "small-xxx-small" mutations in glycophorin A (GpA) and bacteriophage M13 major coat protein (MCP)...
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