Article
A rivet model for channel formation by aerolysin-like pore-forming toxins.
The EMBO journal - 8 Feb 2006
Iacovache Ioan, Paumard Patrick, Scheib Holger, Lesieur Claire, Sakai Naomi, Matile Stefan, Parker Michael W, van der Goot F Gisou
Abstract excerpt
The bacterial toxin aerolysin kills cells by forming heptameric channels, of unknown structure, in the plasma membrane. Using disulfide trapping and cysteine scanning mutagenesis coupled to thiol-specific labeling on lipid bilayers, we identify a loop that lines the channel. This loop has an alternating pattern of charged and uncharged residues, suggesting that the transmembrane region has a beta-barrel...
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