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Article

Mutations in interaction surfaces differentially impact E. coli Hfq association with small RNAs and their mRNA targets.

Journal of molecular biology - 9 Oct 2013

Zhang Aixia, Schu Daniel J, Tjaden Brian C, Storz Gisela, Gottesman Susan

Abstract excerpt

The RNA chaperone protein Hfq is required for the function of all small RNAs (sRNAs) that regulate mRNA stability or translation by limited base pairing in Escherichia coli. While there have been numerous in vitro studies to characterize Hfq activity and the importance of specific residues, there has been only limited characterization of Hfq mutants in vivo. Here, we use a set of reporters as well as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23318956
DOI: 10.1016/j.jmb.2013.01.006
PMCID: PMC3640674

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Mutations in interaction surfaces differentially impact E. coli Hfq association with small RNAs and their mRNA targets.PMID 23318956Read ↗

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