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Article

Conserved arginines on the rim of Hfq catalyze base pair formation and exchange.

Nucleic acids research - 1 Aug 2013

Panja Subrata, Schu Daniel J, Woodson Sarah A

Abstract excerpt

The Sm-like protein Hfq is required for gene regulation by small RNAs (sRNAs) in bacteria and facilitates base pairing between sRNAs and their mRNA targets. The proximal and distal faces of the Hfq hexamer specifically bind sRNA and mRNA targets, but they do not explain how Hfq accelerates the formation and exchange of RNA base pairs. Here, we show that conserved arginines on the outer rim of the hexamer that are...

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Identifiers

PMID: 23771143
DOI: 10.1093/nar/gkt521
PMCID: PMC3753642

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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