Article
Methods for Isolating and Defining Single-Cell Transcriptomes of Tissue-Resident Human NK Cells.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2022
Hashemi Elaheh, Mei Ao, Wang Dandan, Khalil Mohamed, Malarkannan Subramaniam
Abstract excerpt
Natural killer (NK) cells are innate lymphocytes that control tumors and microbial infections. Human NK cells are transcriptomically and phenotypically heterogeneous. The site where NK cells develop and reside determines their phenotype and effector functions. Our current knowledge about human NK cells is primarily from blood- and bone marrow-derived NK cells. The major limitation in formulating organ-specific...
Topics
- Gene Expression Profiling
- Gene Expression Regulation
- Humans
- Killer Cells, Natural
- Phenotype
- Transcriptome