Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Common genetic variants of TP53 and BRCA2 in esophageal cancer patients and healthy individuals from low and high risk areas of northern China.

Cancer detection and prevention - 1 Jan 2003

Hu Nan, Li Wen-Jun, Su Hua, Wang Chaoyu, Goldstein A M, Albert P S, Emmert-Buck M R, Kong Li-Hui, Roth M J, Dawsey S M, He Li-Ji, Cao Shu-Fen, Ding Ti, Giffen Carol, Taylor P R

Abstract excerpt

TP53 and BRCA2 are frequently mutated in cancer and polymorphisms of these genes may modify cancer risk. We used SSCP and DNA sequencing to assess and compare frequencies of R72P (TP53) and 5'UTR203G>A, N372H, and K1132K (BRCA2) polymorphisms in healthy Chinese subjects at varying risk for esopha...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Squamous Cell
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Esophageal Neoplasms

Share to Gene Frequency

Share to Genes, BRCA2

Share to Genes, p53

Share to Polymorphism, Single-Stranded Conformational

Source

Identifiers

PMID: 12670525
DOI: 10.1016/s0361-090x(03)00031-x

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12670525-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Common genetic variants of TP53 and BRCA2 in esophageal cancer patients and healthy individuals from low and high risk areas of northern China.PMID 12670525Read ↗

Frequent inactivation of the TP53 gene in esophageal squamous cell carcinoma from a high-risk population in China.Semantic proximity Read ↗

Frequent germline mutation in the BRCA2 gene in esophageal squamous cell carcinoma patients from a low-risk Chinese population.Semantic proximity Read ↗

A Single nucleotide polymorphism in the ALDH2 gene modifies the risk of esophageal squamous cell carcinoma in BRCA2 p.K3326* carriers.Semantic proximity Read ↗

Pro variant of TP53 Arg72Pro contributes to esophageal squamous cell carcinoma risk: evidence from a meta-analysis.Semantic proximity Read ↗

Analysis of TP53 polymorphisms in North Indian sporadic esophageal cancer patients.Semantic proximity Read ↗

TP53 Pro72 allele is enriched in oral tongue cancer and frequently mutated in esophageal cancer in India.Semantic proximity Read ↗

A Shared Susceptibility Locus in the p53 Gene for both Gastric and Esophageal Cancers in a Northwestern Chinese Population.Semantic proximity Read ↗

Distinct pattern of TP53 mutations in squamous cell carcinoma of the esophagus in Iran.Semantic proximity Read ↗

Genetic polymorphisms of p53 and GSTP1,but not NAT2,are associated with susceptibility to squamous-cell carcinoma of the esophagus.Semantic proximity Read ↗

Alterations of the TP53 gene in gastric and esophageal carcinogenesis.Semantic proximity Read ↗

DHPLC is superior to SSCP in screening p53 mutations in esophageal cancer tissues.Semantic proximity Read ↗

Association of the p53 Arg72Pro polymorphism with esophageal cancer in Chinese populations: a meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.