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Article

Cleavage of double-stranded RNA by RNase HI from a thermoacidophilic archaeon, Sulfolobus tokodaii 7.

Nucleic acids research - 1 Jan 2004

Ohtani Naoto, Yanagawa Hiroshi, Tomita Masaru, Itaya Mitsuhiro

Abstract excerpt

ST0753, the orthologous gene of Type 1 RNase H found in a thermoacidophilic archaeon, Sulfolobus tokodaii, was analyzed. The recombinant ST0753 protein exhibited RNase H activity in both in vivo and in vitro assays. The protein expressed in an RNase H-deficient mutant Escherichia coli strain functioned to suppress the temperature-sensitive phenotype associated with the lack of RNase H. The in vitro...

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Identifiers

PMID: 15520465
DOI: 10.1093/nar/gkh917
PMCID: PMC528802

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Source receipt: pubmed, retrieved 7 Sept 2026.

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