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Article

Prevention of beta strand movement into a zymogen-like position does not confer higher activity to coagulation factor VIIa.

Biochemistry - 9 Nov 2004

Olsen Ole H, Nielsen Per F, Persson Egon

Abstract excerpt

Coagulation factor VIIa (FVIIa) belongs to the chymotrypsin family of S1 peptidases, whose members require the cleavage of at least one internal peptide bond to attain an active conformation. FVIIa also requires association with tissue factor (TF) to attain full catalytic competency. Without this, FVIIa has very low activity toward peptide and physiologic substrates. Reregistration of beta strands has been...

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Identifiers

PMID: 15518559
DOI: 10.1021/bi048721o

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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