Arg-129 plays a specific role in the conformation of antithrombin and in the enhancement of factor Xa inhibition by the pentasaccharide sequence of heparin.

doi:10.1016/0925-4439(94)90070-1

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Article

Arg-129 plays a specific role in the conformation of antithrombin and in the enhancement of factor Xa inhibition by the pentasaccharide sequence of heparin.

Biochimica et biophysica acta - 11 Jan 1994

Najjam S, Chadeuf G, Gandrille S, Aiach M

Abstract excerpt

Small amounts of a variant antithrombin (AT) bearing an Arg-129 to Gln mutation were purified from plasma by means of affinity chromatography on insolubilized heparin at very low ionic strength. As a control, two variant antithrombins, one bearing a Pro-41 to Leu mutation and the other an Arg-47...

Topics

Antithrombins
Arginine
Factor Xa Inhibitors
Heparin
Humans
Kinetics
Mutation
Oligosaccharides
Protein Conformation

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