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Article

Cleavage at Arg-1689 influences heavy chain cleavages during thrombin-catalyzed activation of factor VIII.

The Journal of biological chemistry - 24 Apr 2009

Newell Jennifer L, Fay Philip J

Abstract excerpt

The procofactor, factor VIII, is activated by thrombin or factor Xa-catalyzed cleavage at three P1 residues: Arg-372, Arg-740, and Arg-1689. The catalytic efficiency for thrombin cleavage at Arg-740 is greater than at either Arg-1689 or Arg-372 and influences reaction rates at these sites. Because cleavage at Arg-372 appears rate-limiting and dependent upon initial cleavage at Arg-740, we investigated whether...

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Source

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Identifiers

PMID: 19240027
DOI: 10.1074/jbc.M900234200
PMCID: PMC2670113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cleavage at Arg-1689 influences heavy chain cleavages during thrombin-catalyzed activation of factor VIII.PMID 19240027Read ↗

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