Article
Mass spectrometry provides accurate characterization of two genetic marker types in Bacillus anthracis.
BioTechniques - 1 Oct 2004
Van Ert Matthew N, Hofstadler Steven A, Jiang Yun, Busch Joseph D, Wagner David M, Drader Jared J, Ecker David J, Hannis James C, Huynh Lynn Y, Schupp James M, Simonson Tatum S, Keim Paul
Abstract excerpt
Epidemiological and forensic analyses of bioterrorism events involving Bacillus anthracis could be improved if both variable number tandem repeats (VNTRs) and single nucleotide polymorphisms (SNPs) could be combined on a single analysis platform. Here we present the use of electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI-FTICR-MS) to characterize 24 alleles from 6 VNTR loci...
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