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Article

Strain-specific single-nucleotide polymorphism assays for the Bacillus anthracis Ames strain.

Journal of clinical microbiology - 1 Jan 2007

Van Ert Matthew N, Easterday W Ryan, Simonson Tatum S, U'Ren Jana M, Pearson Talima, Kenefic Leo J, Busch Joseph D, Huynh Lynn Y, Dukerich Megan, Trim Carla B, Beaudry Jodi, Welty-Bernard Amy, Read Timothy, Fraser Claire M, Ravel Jacques, Keim Paul

Abstract excerpt

Highly precise diagnostics and forensic assays can be developed through a combination of evolutionary analysis and the exhaustive examination of genomic sequences. In Bacillus anthracis, whole-genome sequencing efforts revealed ca. 3,500 single-nucleotide polymorphisms (SNPs) among eight different strains and evolutionary analysis provides the identification of canonical SNPs. We have previously shown that SNPs...

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Identifiers

PMID: 17093023
DOI: 10.1128/JCM.01233-06
PMCID: PMC1828967

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