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Article

Telomerase regulation by the long non-coding RNA H19 in human acute promyelocytic leukemia cells

27 Apr 2018

Abstract excerpt

BACKGROUND: Since tumor growth requires reactivation of telomerase (hTERT), this enzyme is a challenging target for drug development. Therefore, it is of great interest to identify telomerase expression and activity regulators. Retinoids are well-known inducers of granulocytic maturation associated with hTERT repression in acute promyelocytic leukemia (APL) blasts. In a maturation-resistant APL cell line, we have...

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PMID: 29703210
DOI: 10.1186/s12943-018-0835-8

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