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Article

Generation of an ABCG2(GFPn-puro) transgenic line--a tool to study ABCG2 expression in mice.

Biochemical and biophysical research communications - 26 Jun 2009

Orford Michael, Mean Richard, Lapathitis George, Genethliou Nicholas, Panayiotou Elena, Panayi Helen, Malas Stavros

Abstract excerpt

The ATP-binding cassette (ABC) transporter 2 (ABCG2) is expressed by stem cells in many organs and in stem cells of solid tumors. These cells are isolated based on the side population (SP) phenotype, a Hoechst 3342 dye efflux property believed to be conferred by ABCG2. Because of the limitations of this approach we generated transgenic mice that express Nuclear GFP (GFPn) coupled to the Puromycin-resistance gene,...

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Topics

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Share to Antimetabolites, Antineoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Drug Resistance, Neoplasm

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Source

Identifiers

PMID: 19393620
DOI: 10.1016/j.bbrc.2009.04.089

Genes

ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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